Pubs, bars, restaurants and cafes across central Scotland, including Glasgow and Edinburgh, will be forced to close for two weeks from Friday.
They will still be able to offer a takeaway service.
Those outside these areas will be unable to sell alcohol indoors for 16 days from Friday at 18:00, First Minister Nicola Sturgeon said.
Indoor food sales will be allowed until 18:00.
Outdoor sales of alcohol will still be allowed until 22:00.
She said “none of this is easy” and added that she was aware that with every decision “lives and jobs are at stake”.
Sturgeon said that with the rise of infections “we need to do more and we need to do it now”